Back to search

Article

Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease

2024-01-15

Abstract excerpt

<h4>Background: </h4> Tubulointerstitial fibrosis plays an important role in the progression of diabetic kidney disease (DKD). Sacubitril/valsartan (Sac/Val) exerts a robust beneficial effect in DKD. However, the potential functional effect of Sac/Val on tubulointerstitial fibrosis in DKD is still largely unclear. Methods Streptozotocin-induced diabetic mice were given Sac/Val or Val by intragastric administratio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
61ae3c1c-36aa-529e-8635-96b135350f07
DOI
10.21203/rs.3.rs-3850299/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney diseaseDOI 10.21203/rs.3.rs-3850299/v1
TFAM and Mitochondrial Protection in Diabetic Kidney DiseaseSemantic proximity
Roles of SIRT6 in kidney disease: a novel therapeutic targetSemantic proximity
Network pharmacology and experimental validation of andrographolide’s renoprotective effects on diabetic nephropathy via AGEs-RAGE signaling and mitophagy pathwaysSemantic proximity
SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation.Semantic proximity
LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney diseaseSemantic proximity
Identifying Key Genes for Diabetic Kidney Disease by Bioinformatics AnalysisSemantic proximity
Kidney single-cell transcriptomes uncover SGLT2i-induced metabolic reprogramming via restoring glycolysis and fatty acid oxidationSemantic proximity
Sirtuins in kidney diseases: potential mechanism and therapeutic targetsSemantic proximity
Increased SUMO-activating enzyme subunit 1 promotes glycolysis and fibrotic phenotype of diabetic nephropathy.Semantic proximity
Asprosin Promotes High Glucose-Induced Apoptosis of Human Renal Tubular Epithelial Cells by Inhibiting AutophagySemantic proximity
Comprehensive circRNA Expression Profile and Transcriptomics-Based Molecular Pathway Analysis of the Sodium-Glucose Co-Transporter-2 Inhibitor Dapagliflozin in Diabetic Tubular Epithelial CellsSemantic proximity
Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in miceSemantic proximity
Select a neighboring publication to make it the new centre.