Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-1225-3p regulates fibrosis in mesangial cells via SMURF2-mediated ubiquitination of ChREBP in diabetic kidney disease

11 Apr 2025

Abstract excerpt

BACKGROUND: Diabetic kidney disease (DKD), characterized by mesangial fibrosis and renal dysfunction, is a major microvascular complication of diabetes. Studies have shown that miRNAs are closely related to the progression of DKD. Therefore, in this study, we aimed to explore whether miR-1225-3p can regulate Smad ubiquitin regulatory factor 2 (SMURF2)-mediated carbohydrate response element binding protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol and Lipid Metabolism
Share to Chronic Kidney Disease and Diabetes
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40211762
DOI: 10.1080/0886022x.2025.2484632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-1225-3p regulates fibrosis in mesangial cells via SMURF2-mediated ubiquitination of ChREBP in diabetic kidney diseasePMID 40211762Read ↗

Identification and validation of immune-related biomarkers and potential regulators and therapeutic targets for diabetic kidney diseaseSemantic proximity Read ↗

Bioinformatics prediction and experimental verification of key biomarkers for diabetic kidney disease based on transcriptome sequencing in miceSemantic proximity Read ↗

Impact of klotho on the expression of SRGAP2a in podocytes in diabetic nephropathySemantic proximity Read ↗

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signalingSemantic proximity Read ↗

Long non-coding RNA L13Rik promotes high glucose-induced mesangial cell injury by regulating miR-2861/CDKN1B axisSemantic proximity Read ↗

Identification of Smad3-related transcriptomes in type-2 diabetic nephropathy by whole transcriptome RNA sequencing.Semantic proximity Read ↗

Potential Targeting of Renal Fibrosis in Diabetic Kidney Disease Using MicroRNAsSemantic proximity Read ↗

Early growth response protein-1 upregulates long noncoding RNA Arid2-IR to promote extracellular matrix production in diabetic kidney diseaseSemantic proximity Read ↗

miR-299a-5p is a novel mediator of fibrosis in diabetic kidney disease through its regulation of antifibrotic proteins follistatin and cripto-1Semantic proximity Read ↗

Natural products targeting ubiquitination to combat kidney fibrosisSemantic proximity Read ↗

SGLT2 inhibitor empagliflozin ameliorates tubulointerstitial fibrosis in DKD by downregulating renal tubular PKM2Semantic proximity Read ↗

Progress of small ubiquitin-related modifiers in kidney diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.