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Article

Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys

2020-12-16

Abstract excerpt

<h4>Summary</h4> Defects in endothelial cells cause deterioration in kidney function and structure. Here, we found that endothelial SIRT3 regulates metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice. By analyzing, gain-of-function of the SIRT3 gene by overexpression in a fibrotic mouse strain conferred disease resistance against diabetic kidney fibrosis; while its loss-of-function in endothe...

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Identifiers and source

Literature Corpus work
2fd3981e-c9ad-5943-a712-d65800fbf1dc
DOI
10.1101/2020.12.15.422824
Open publication

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Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneysDOI 10.1101/2020.12.15.422824
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