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Article

Distinct routes of clonal progression in SF3B1-mutant myelodysplastic syndromes.

Blood advances - 24 Jun 2025

Sarchi Martina, Clough Courtnee A, Gallì Anna, Picone Cristina, Ferrari Beatrice, Crosse Edie I, Baquero Galvis Laura D, Fiducioso Claudia, Aydinyan Nelli, Creamer J Philip, Pozzi Sara, Molteni Elisabetta, Elena Chiara, Bradley Robert K, Malcovati Luca, Doulatov Sergei

Abstract excerpt

ABSTRACT: Myelodysplastic syndromes (MDS) are clonal stem cell disorders driven by heterogeneous genetic alterations leading to variable clinical course. MDS with splicing factor SF3B1 mutations is a distinct subtype with a favorable outcome. However, selected comutations induce poor prognosis and how these genetic lesions cooperate in human hematopoietic stem and progenitor cells (HSPCs) during disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40188457
DOI: 10.1182/bloodadvances.2024014965
PMCID: PMC12209948

Genes

SF3B1
RUNX1
STAG2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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