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Article

m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis.

Molecular cell - 6 Apr 2023

Cieśla Maciej, Ngoc Phuong Cao Thi, Muthukumar Sowndarya, Todisco Gabriele, Madej Magdalena, Fritz Helena, Dimitriou Marios, Incarnato Danny, Hellström-Lindberg Eva, Bellodi Cristian

Abstract excerpt

SF3B1 is the most mutated splicing factor (SF) in myelodysplastic syndromes (MDSs), which are clonal hematopoietic disorders with variable risk of leukemic transformation. Although tumorigenic SF3B1 mutations have been extensively characterized, the role of "non-mutated" wild-type SF3B1 in cancer remains largely unresolved. Here, we identify a conserved epitranscriptomic program that steers SF3B1 levels to...

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Carcinogenesis
Leukemia
Mice
Mutation
Myelodysplastic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoproteins

RNA Splicing Factors

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PMID: 36944332
DOI: 10.1016/j.molcel.2023.02.024

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