Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytogenetic signatures favoring metastatic organotropism in colorectal cancer

5 Apr 2025

Abstract excerpt

Colorectal carcinoma (CRC) exhibits metastatic organotropism, primarily targeting liver, lung, and rarely the brain. Here, we study chromosomal imbalances (CIs) in cohorts of primary CRCs and metastases. Brain metastases show the highest burden of CIs, including aneuploidies and focal CIs, with enrichment of +12p encoding KRAS. Compared to liver and lung metastases, brain metastases present with increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Genomic variations and chromosomal abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40188208
DOI: 10.1038/s41467-025-58413-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytogenetic signatures favoring metastatic organotropism in colorectal cancerPMID 40188208Read ↗

The Molecular Signature of Early-Onset Colorectal Cancer Liver Metastases: Distinct Biology and Clinical Challenges.Semantic proximity Read ↗

Genomic mapping of metastatic organotropism in lung adenocarcinoma.Semantic proximity Read ↗

High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer.Semantic proximity Read ↗

Genomics correlates of brain metastasis and progression in colorectal cancer.Semantic proximity Read ↗

Genomic evolution and diverse models of systemic metastases in colorectal cancer.Semantic proximity Read ↗

Comparative Genomic Analysis of Primary and Synchronous Metastatic Colorectal CancersSemantic proximity Read ↗

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity.Semantic proximity Read ↗

Molecular Profiling and High-Content Drug Screening of Metastatic Colorectal Cancer Organoids Reveal Evolutionary Mechanisms of Pan-KRAS Inhibitor ResistanceSemantic proximity Read ↗

Genomic determinants of metastatic organotropism and dissemination tempo across 3,368 lung cancersSemantic proximity Read ↗

Transcriptomic Analyses and Novel Organoid and Xenograft Modeling Reveals Potential Drug Sensitivities in a KRAS G12V-Mutant Colorectal Cancer Brain MetastasisSemantic proximity Read ↗

An enhanced genetic model of colorectal cancer progression historySemantic proximity Read ↗

Specific genomic aberrations in primary colorectal cancer are associated with liver metastases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.