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Article

Cytogenetic signatures favoring metastatic organotropism in colorectal cancer.

Nature communications - 5 Apr 2025

Golas Mariola Monika, Gunawan Bastian, Gutenberg Angelika, Danner Bernhard C, Gerdes Jan S, Stadelmann Christine, Füzesi Laszlo, Liersch Torsten, Sander Bjoern

Abstract excerpt

Colorectal carcinoma (CRC) exhibits metastatic organotropism, primarily targeting liver, lung, and rarely the brain. Here, we study chromosomal imbalances (CIs) in cohorts of primary CRCs and metastases. Brain metastases show the highest burden of CIs, including aneuploidies and focal CIs, with enrichment of +12p encoding KRAS. Compared to liver and lung metastases, brain metastases present with increased...

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Identifiers

PMID: 40188208
DOI: 10.1038/s41467-025-58413-1
PMCID: PMC11972295

Genes

KRAS
CDK4
MDM2

Provenance

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