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Article

The Molecular Signature of Early-Onset Colorectal Cancer Liver Metastases: Distinct Biology and Clinical Challenges.

International journal of molecular sciences - 4 Apr 2026

Tsokkou Sophia, Konstantinidis Ioannis, Chatzikomnitsa Paraskevi, Papakonstantinou Menelaos, Gkaitatzi Areti Danai, Toutziari Evdokia, Alexandrou Dimitrios, Giakoustidis Dimitrios, Papadopoulos Vasileios N, Giakoustidis Alexandros

Abstract excerpt

Early-onset colorectal cancer (EOCRC), defined as diagnosis before the age of 50 years, is increasing globally and is frequently characterized by aggressive biology and a disproportionate burden of liver metastases. This review synthesizes emerging evidence on the distinct molecular, immunologic and clinical features that differentiate EOCRC liver metastases from those arising in older adults. Genomic studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41977468
DOI: 10.3390/ijms27073289
PMCID: PMC13073341

Genes

GNAS
MAPK1
MYC
PIK3CA
RAD21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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