Genomic mapping of metastatic organotropism in lung adenocarcinoma.

doi:10.1016/j.ccell.2023.03.018

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Article

Genomic mapping of metastatic organotropism in lung adenocarcinoma.

Cancer cell - 8 May 2023

Lengel Harry B, Mastrogiacomo Brooke, Connolly James G, Tan Kay See, Liu Yuan, Fick Cameron N, Dunne Elizabeth G, He Di, Lankadasari Manendra B, Satravada Baby Anusha, Sun Yichao, Kundra Ritika, Fong Chris, Smith Shaleigh, Riely Gregory J, Rudin Charles M, Gomez Daniel R, Solit David B, Berger Michael F, Li Bob T, Mayo Marty W, Matei Irina, Lyden David C, Adusumilli Prasad S, Schultz Nikolaus, Sanchez-Vega Francisco, Jones David R

Abstract excerpt

We analyzed 2,532 lung adenocarcinomas (LUAD) to identify the clinicopathological and genomic features associated with metastasis, metastatic burden, organotropism, and metastasis-free survival. Patients who develop metastasis are younger and male, with primary tumors enriched in micropapillary or solid histological subtypes and with a higher mutational burden, chromosomal instability, and fraction of genome...

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Identifiers

PMID: 37084736
DOI: 10.1016/j.ccell.2023.03.018
PMCID: PMC10391526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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