Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation

25 Feb 2016

Abstract excerpt

Meiotic recombination is induced by the formation of DNA double-strand breaks (DSBs) catalyzed by SPO11, the ortholog of subunit A of TopoVI DNA topoisomerase (TopoVIA). TopoVI activity requires the interaction between A and B subunits. We identified a conserved family of plant and animal proteins [the TOPOVIB-Like (TOPOVIBL) family] that share strong structural similarity to the TopoVIB subunit of TopoVI DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to DNA Repair Mechanisms
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26917764
DOI: 10.1126/science.aad5309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The TopoVIB-Like protein family is required for meiotic DNA double-strand break formationPMID 26917764Read ↗

A DNA topoisomerase VI–like complex initiates meiotic recombinationSemantic proximity Read ↗

Spo11: from topoisomerase VI to meiotic recombination initiatorSemantic proximity Read ↗

Mechanism and control of meiotic recombination initiation.Semantic proximity Read ↗

Structural and functional characterization of the Spo11 core complex.Semantic proximity Read ↗

Meiotic recombination: breaking the genome to save it.Semantic proximity Read ↗

Homologous recombinational repair proteins in mouse meiosisSemantic proximity Read ↗

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genomeSemantic proximity Read ↗

In vitro reconstitution of meiotic DNA double-strand-break formationSemantic proximity Read ↗

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genomeSemantic proximity Read ↗

Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination.Semantic proximity Read ↗

Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.Semantic proximity Read ↗

Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.