Article
Both conserved and non-conserved regions of Spo11 are essential for meiotic recombination initiation in yeast.
Molecular genetics and genomics : MGG - 1 Oct 2006
Nag Dilip K, Pata Janice D, Sironi Manuela, Flood David R, Hart Ashley M
Abstract excerpt
DNA double-strand breaks (DSBs) are the initiators of most meiotic recombination events. In Saccharomyces cerevisiae, at least ten genes are necessary for meiotic DSB formation. However, the molecular roles of these proteins are not clearly understood. The meiosis-specific Spo11 protein, which shows sequence similarity with a subunit of an archaeal topoisomerase, is believed to catalyze the meiotic DSB formation....
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