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Article

High throughput sequencing reveals alterations in the recombination signatures with diminishing Spo11 activity.

PLoS genetics - 1 Oct 2013

Rockmill Beth, Lefrançois Philippe, Voelkel-Meiman Karen, Oke Ashwini, Roeder G Shirleen, Fung Jennifer C

Abstract excerpt

Spo11 is the topoisomerase-like enzyme responsible for the induction of the meiosis-specific double strand breaks (DSBs), which initiates the recombination events responsible for proper chromosome segregation. Nineteen PCR-induced alleles of SPO11 were identified and characterized genetically and cytologically. Recombination, spore viability and synaptonemal complex (SC) formation were decreased to varying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Crossing Over, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 24204324
DOI: 10.1371/journal.pgen.1003932
PMCID: PMC3814317

Genes

SPO11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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