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Article

Intergenerational transmission of complex traits and the offspring methylome.

Molecular psychiatry - 1 Jul 2025

Hagenbeek Fiona A, Pool René, Van Asselt Austin J, Ehli Erik A, Smit August B, Bartels Meike, Hottenga Jouke Jan, Dolan Conor V, van Dongen Jenny, Boomsma Dorret I

Abstract excerpt

The genetic makeup of parents can directly or indirectly affect their offspring phenome through genetic transmission or via the environment that is influenced by parental heritable traits. Our understanding of the mechanisms by which indirect genetic effects operate is limited. Here, we hypothesize that one mechanism is via the offspring methylome. To test this hypothesis, polygenic scores (PGSs) for...

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Topics

Humans
DNA Methylation
Female
Male
Child
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Schizophrenia

Epigenome

Adult

Body Mass Index

Cohort Studies

Phenotype

Parents

Epigenesis, Genetic

Smoking

Educational Status

Source

Open in PubMed Open full text

Identifiers

PMID: 40181191
DOI: 10.1038/s41380-025-02981-7
PMCID: PMC12185334

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