Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.

doi:10.1038/s41398-020-01147-z

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Article

Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.

Translational psychiatry - 1 Feb 2021

Czamara Darina, Tissink Elleke, Tuhkanen Johanna, Martins Jade, Awaloff Yvonne, Drake Amanda J, Khulan Batbayar, Palotie Aarno, Winter Sibylle M, Nemeroff Charles B, Craighead W Edward, Dunlop Boadie W, Mayberg Helen S, Kinkead Becky, Mathew Sanjay J, Iosifescu Dan V, Neylan Thomas C, Heim Christine M, Lahti Jari, Eriksson Johan G, Räikkönen Katri, Ressler Kerry J, Provençal Nadine, Binder Elisabeth B

Abstract excerpt

Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main effects of such exposure on epigenetic measures, including DNA methylation (DNAm), are inconsistent. Studies in perinatal tissues indicate that variability of DNAm at birth is best explained by the joint effects of genotype and...

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Identifiers

PMID: 33526782
DOI: 10.1038/s41398-020-01147-z
PMCID: PMC7851167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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