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Direct and indirect genetic effects of birthweight predisposition on child DNA methylation at birth.

Epigenetics - 1 Dec 2026

Creasey Nicole, Frach Leonard, Isaevska Elena, Felix Janine F, Cecil Charlotte, Pingault Jean-Baptiste, Neumann Alexander

Abstract excerpt

Birthweight is heritable and strongly associated with epigenetic differences at birth. It is unclear whether a genetic birthweight score is associated with DNA methylation (DNAm) and, if so, whether through direct genetic effects (i.e. child genotype) or indirect genetic effects (i.e. parental genotype, independent of child genotype), which are suspected to be mediated by the prenatal environment (e.g. metabolic...

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Identifiers

PMID: 41979563
DOI: 10.1080/15592294.2026.2654101
PMCID: PMC13081746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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