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Article

CircTADA2A stabilizes p53 via interacting with TRIM28 and suppresses the maintenance of FLT3-ITD acute myeloid leukemia.

Leukemia - 1 Jun 2025

Li Ran, Wu Xiaolu, Xue Kai, Wu Shishuang, Jiang Ge, He Mengke, Xia Yi, Liu Hailing, Zhong Miao, Li Jianyong, Fan Lei, Li Junmin

Abstract excerpt

Internal tandem duplication mutations in the FMS-like tyrosine kinase 3 (FLT3-ITDs) occur in 25%-30% of acute myeloid leukemia (AML) cases and are associated with adverse prognosis. RNA-based therapeutics exhibit significant potential for treating diseases, prompting us to develop a novel circular RNA (circRNA)-based therapeutic strategy for FLT3-ITD AML. Here, we find circTADA2A is downregulated in FLT3-ITD AML...

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Share to Cell Proliferation
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to RNA, Circular

Share to Tandem Repeat Sequences

Share to Tumor Suppressor Protein p53

Share to Ubiquitination

Source

Identifiers

PMID: 40175625
DOI: 10.1038/s41375-025-02589-4

Genes

FLT3
TRIM28
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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