<i>circPCMTD1</i> : A protein-coding circular RNA that regulates DNA damage response in <i>BCR/ABL</i> -positive leukemias

Abstract excerpt

Circular RNAs are a novel class of RNA transcripts, which regulate important cellular functions in health and disease. Herein, we report on the functional relevance of the circPCMTD1 transcript in acute leukemias. In screening experiments, we found that circPCMTD1 depletion strongly inhibited the proliferative capacity of leukemic cells with BCR-ABL translocations. Mass cytometry experiments identified the aber...

Topics

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• Circular RNAs in diseases
• Gene Expression Regulation, Leukemic
• Gene Regulatory Networks
• K562 Cells
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive
• MicroRNA in disease regulation
• RNA
• RNA, Circular

Identifiers and source

Literature Corpus work

2dd685a0-7cf3-5eee-a48d-f822e6eb3e4f

DOI

10.1101/2024.06.27.601046