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Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

7 Sept 2020

Abstract excerpt

BACKGROUND: Inactivation of the tumor suppressor p53 is critical for pathogenesis of glioma, in particular glioblastoma multiforme (GBM). MDM2, the main negative regulator of p53, binds to and forms a stable complex with p53 to regulate its activity. Hitherto, it is unclear whether the stability of the p53/MDM2 complex is affected by lncRNAs, in particular circular RNAs that are usually abundant and conserved,...

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PMID: 32894144
DOI: 10.1186/s12943-020-01253-y

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