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Inducing TRIB2 Targeted Protein Degradation to Reverse Chemoresistance in Acute Myeloid Leukaemia

2025-10-05

Abstract excerpt

The myeloid oncogene TRIB2 is a key driver of acute myeloid leukaemia (AML) pathogenesis, promoting chemoresistance and blocking differentiation through ubiquitin-mediated degradation of the C/EBPα transcription factor. Despite its stable and sometimes elevated expression across AML subtypes, TRIB2 remains a clinically-untargeted vulnerability. Here, we present a comprehensive investigation into TRIB2 degradation...

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Literature Corpus work
77f50927-45c7-5c80-8526-ba913a95f0e4
DOI
10.1101/2025.10.03.680259
Open publication

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Inducing TRIB2 Targeted Protein Degradation to Reverse Chemoresistance in Acute Myeloid LeukaemiaDOI 10.1101/2025.10.03.680259
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