Article

Alternative back-splicing of circular RNAs modulates almonertinib resistance in non-small cell lung cancer

2026-05-21

Abstract excerpt

<title>Abstract</title> <p>Acquired resistance to third-generation EGFR tyrosine kinase inhibitors (TKIs) such as almonertinib presents a major clinical challenge in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are generated via back-splicing, and are versatile players in cancer biology. By using long-read nanopore sequencing, we profiled full-length circRNAs in almonertinib-resistant NSCLC cells...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7dd42b5-dd3d-5d1d-baa6-7c7266112dff
DOI: 10.21203/rs.3.rs-9505749/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alternative back-splicing of circular RNAs modulates almonertinib resistance in non-small cell lung cancerDOI 10.21203/rs.3.rs-9505749/v1Read

Circular RNA SPECC1 promoted tumorigenesis and osimertinib resistance in lung adenocarcinoma via a circular RNA-microRNA networkSemantic proximity Read

Characterization of circRNAs in established osimertinib‑resistant non‑small cell lung cancer cell linesSemantic proximity Read

Unveiling Pharmacogenomics Insights into Circular RNAs: Toward Precision Medicine in Cancer TherapySemantic proximity Read

Elevated circASCC3 Suppresses Antitumor Immunity by Sponging miR-432-5p to Upregulate C5a in Non-small-cell Lung CancerSemantic proximity Read

Functional landscape of circular RNAs in human cancer cellsSemantic proximity Read

Circular RNA EPB41 Expression Predicts Unfavorable Prognoses in NSCLC by Regulating miR-486-3p/eIF5A Axis-Mediated StemnessSemantic proximity Read

Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarizationSemantic proximity Read

Integrated transcriptomic and machine learning-driven analysis reveals high-confidence circular RNA biomarkers in Lung AdenocarcinomaSemantic proximity Read

CircRNAs in anticancer drug resistance: recent advances and future potentialSemantic proximity Read

Exosomal non-coding RNAs-mediated EGFR-TKIs resistance in NSCLC with EGFR mutation.Semantic proximity Read

CircRNA-mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance via PSIP1/c-Myc Axis Nuclear Translocation and Partially through Increasing EGFR ExpressionSemantic proximity Read

Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune EvasionSemantic proximity Read