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Article

miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

26 Apr 2016

Abstract excerpt

MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast cancer, here we show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) where it is significantly downregulated. Forced expression of miR-22 significantly suppresses leukaemic cell viability and...

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PMID: 27116251
DOI: 10.1038/ncomms11452

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