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Article

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.

Nature human behaviour - 1 May 2025

Malone Samantha G, Davis Christal N, Piserchia Zachary, Setzer Michael R, Toikumo Sylvanus, Zhou Hang, Winterlind Emma L, Gelernter Joel, Justice Amy, Leggio Lorenzo, Rentsch Christopher T, Kranzler Henry R, Gray Joshua C

Abstract excerpt

Despite neurobiological overlap, alcohol use disorder (AUD) and body mass index (BMI) show minimal genetic correlation (rg), possibly due to mixed directions of shared variants. Here we applied MiXeR to investigate shared genetic architecture between AUD and BMI, conjunctional false discovery rate to detect shared loci and their directional effect, local analysis of (co)variant association for local rg,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 40164914
DOI: 10.1038/s41562-025-02148-y
PMCID: PMC13007225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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