Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings.

doi:10.1038/s41386-022-01401-6

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Article

Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2022

Icick Romain, Shadrin Alexey, Holen Børge, Karadag Naz, Lin Aihua, Hindley Guy, O'Connell Kevin, Frei Oleksandr, Bahrami Shahram, Høegh Margrethe Collier, Cheng Weiqiu, Fan Chun C, Djurovic Srdjan, Dale Anders M, Lagerberg Trine Vik, Smeland Olav B, Andreassen Ole A

Abstract excerpt

Alcohol use disorder (AUD) is a pervasive and devastating mental illness with high comorbidity rates with other mental disorders. Understanding the genetic architecture of this comorbidity could be improved by focusing on intermediate traits that show positive genetic correlation with the disorders. Thus, we aimed to characterize the shared vs. unique polygenicity of AUD, alcohol consumption (AC) and mood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35953530
DOI: 10.1038/s41386-022-01401-6
PMCID: PMC9485134

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