Article
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.
Psychological medicine - 1 Mar 2023
Johnson Emma C, Kapoor Manav, Hatoum Alexander S, Zhou Hang, Polimanti Renato, Wendt Frank R, Walters Raymond K, Lai Dongbing, Kember Rachel L, Hartz Sarah, Meyers Jacquelyn L, Peterson Roseann E, Ripke Stephan, Bigdeli Tim B, Fanous Ayman H, Pato Carlos N, Pato Michele T, Goate Alison M, Kranzler Henry R, O'Donovan Michael C, Walters James T R, Gelernter Joel, Edenberg Howard J, Agrawal Arpana
Abstract excerpt
BACKGROUND: Alcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and large-scale genome-wide association studies (GWAS) have identified significant genetic correlations between these disorders. METHODS: We used the largest published GWAS for AUD (total cases = 77 822) and SCZ (total cases = 46 827) to identify genetic variants that influence both disorders (with either the same or opposite...
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