Article
Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci.
Addiction (Abingdon, England) - 1 Mar 2022
Wiström Erik D, O'Connell Kevin S, Karadag Naz, Bahrami Shahram, Hindley Guy F L, Lin Aihua, Cheng Weiqiu, Steen Nils Eiel, Shadrin Alexey, Frei Oleksandr, Djurovic Srdjan, Dale Anders M, Andreassen Ole A, Smeland Olav B
Abstract excerpt
BACKGROUND AND AIM: Schizophrenia (SCZ) and bipolar disorder (BD) have a high comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol consumption (AC) have been linked to greater illness severity. We aimed to identify genomic loci jointly associated with SCZ, BD, AUD and AC to gain further insights into their shared genetic architecture. DESIGN: We analysed summary data (P values...
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