Article
Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA.
Communications biology - 29 Jan 2021
Wang Zhen, Maluenda Jérôme, Giraut Laurène, Vieille Thibault, Lefevre Andréas, Salthouse David, Radou Gaël, Moulinas Rémi, Astete Sandra, D'Avezac Pol, Smith Geoff, André Charles, Allemand Jean-François, Bensimon David, Croquette Vincent, Ouellet Jimmy, Hamilton Gordon
Abstract excerpt
Accurate decoding of nucleic acid variation is critical to understand the complexity and regulation of genome function. Here we use a single-molecule magnetic tweezer (MT) platform to identify sequence variation and map a range of important epigenetic base modifications with high sensitivity, specificity, and precision in the same single molecules of DNA or RNA. We have also developed a highly specific...
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