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Clustered regularly interspaced short palindromic repeats (CRISPR)-Diagnostics for differential detection of haemoglobin variant S, C, D and E

2025-08-28

Abstract excerpt

Although haemoglobin variants are prevalent in low- and middle-income countries, the exact disease burden remains unknown due to a lack of diagnostic capacity. Traditionally, routine clinical haemoglobin variant diagnostics have relied on electrophoresis, which separates the haemoglobins based on size and charge differences. However, electrophoresis-based assays are limited in depth and coverage due to their inabi...

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Literature Corpus work: 1a7022d8-dc0b-5f3c-bb2f-8bf6588328f4
DOI: 10.1101/2025.08.26.25334459

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