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Non-Invasive Prenatal Diagnosis of Chromosomal and Monogenic Disease by a Novel Bioinspired Micro–Nanochip for Isolating Fetal Nucleated Red Blood Cells

1 Dec 2024

Abstract excerpt

Purpose: Fetal nucleated red blood cells (fNRBCs) in the peripheral blood of pregnant women contain comprehensive fetal genetic information, making them an ideal target for non-invasive prenatal diagnosis (NIPD). However, challenges in identifying, enriching, and detecting fNRBCs limit their diagnostic potential. Methods: To overcome these obstacles, we developed a novel biomimetic chip, replicating the...

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PMID: 39713222
DOI: 10.2147/ijn.s479297

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