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Article

The C. elegans glutamate transporters GLT-4 and GLT-5 regulate protein expression, behavior, and lifespan.

Neurochemistry international - 1 Jun 2025

Bronstone Grace J, Harton Moriah, Muldowney Maya, Reigle James, Funk Adam J, O'Donovan Sinead M, McCullumsmith Robert E, Bauer Deborah E

Abstract excerpt

Glutamate transporters are important for regulating extracellular glutamate levels, impacting neural function and metabolic homeostasis. This study explores the behavioral, lifespan, and proteomic profiles in Caenorhabditis elegans strains with either glt-4 or glt-5 null mutations, highlighting contrasting phenotypes. Δglt-4 mutants displayed impaired mechanosensory and chemotactic responses, reduced lifespans,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40147734
DOI: 10.1016/j.neuint.2025.105966
PMCID: PMC12053503

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