Article

Spatial Partitioning of Glucose Metabolism Supports Tissue-Specific Metabolic Programs In Vivo

2025-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Tissues exhibit metabolic heterogeneity that tailors conserved pathways to distinct physiological demands, yet how this heterogeneity is achieved in vivo remains poorly understood. Here, we use Caenorhabditis elegans to investigate tissue-specific requirements for glucose-6-phosphate isomerase (GPI-1), a conserved reversible enzyme that links glycolysis and the pentose phosphate pathway (PPP)....

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Literature Corpus work: 543f6da4-8a71-5517-8b6d-d458f39b9c9f
DOI: 10.1101/2025.11.09.687253

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