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Article

Selective tubulin-binding drugs induce pericyte phenotype switching and anti-cancer immunity.

EMBO molecular medicine - 1 May 2025

He Bo, Wood Kira H, Li Zhi-Jie, Ermer Judith A, Li Ji, Bastow Edward R, Sakaram Suraj, Darcy Phillip K, Spalding Lisa J, Redfern Cameron T, Canes Jordi, Oliveira Mafalda, Prat Aleix, Cortes Javier, Thompson Erik W, Littlefield Bruce A, Redfern Andrew, Ganss Ruth

Abstract excerpt

The intratumoral immune milieu is crucial for the success of anti-cancer immunotherapy. We show here that stromal modulation by the tubulin-binding anti-cancer drugs combretastatin A4 (CA-4) and eribulin improved tumor perfusion and anti-tumor immunity. This was achieved by reverting highly proliferative, angiogenic pericytes into a quiescent, contractile state which durably normalized the vascular bed and...

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Identifiers

PMID: 40140727
DOI: 10.1038/s44321-025-00222-6
PMCID: PMC12081767

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