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Article

Perivascular cell-derived extracellular vesicles stimulate colorectal cancer revascularization after withdrawal of antiangiogenic drugs.

Journal of extracellular vesicles - 1 May 2021

Huang Maohua, Chen Minfeng, Qi Ming, Ye Geni, Pan Jinghua, Shi Changzheng, Yang Yunlong, Zhao Luyu, Mo Xukai, Zhang Yiran, Li Yong, Zhong Jincheng, Lu Weijin, Li Xiaobo, Zhang Jiayan, Lin Jinrong, Luo Liangping, Liu Tongzheng, Tang Patrick Ming-Kuen, Hong An, Cao Yihai, Ye Wencai, Zhang Dongmei

Abstract excerpt

Antiangiogenic tyrosine kinase inhibitors (AA-TKIs) have become a promising therapeutic strategy for colorectal cancer (CRC). In clinical practice, a significant proportion of cancer patients temporarily discontinue AA-TKI treatment due to recurrent toxicities, economic burden or acquired resistance. However, AA-TKI therapy withdrawal-induced tumour revascularization frequently occurs, hampering the clinical...

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Identifiers

PMID: 34035882
DOI: 10.1002/jev2.12096
PMCID: PMC8138700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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