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Article

Pericyte phenotype switching alleviates immunosuppression and sensitizes vascularized tumors to immunotherapy in preclinical models.

The Journal of clinical investigation - 17 Sept 2024

Li Zhi-Jie, He Bo, Domenichini Alice, Satiaputra Jiulia, Wood Kira H, Lakhiani Devina D, Bashaw Abate A, Nilsson Lisa M, Li Ji, Bastow Edward R, Johansson-Percival Anna, Denisenko Elena, Forrest Alistair Rr, Sakaram Suraj, Carretero Rafael, Hämmerling Günter J, Nilsson Jonas A, Lee Gabriel Yf, Ganss Ruth

Abstract excerpt

T cell-based immunotherapies are a promising therapeutic approach for multiple malignancies, but their efficacy is limited by tumor hypoxia arising from dysfunctional blood vessels. Here, we report that cell-intrinsic properties of a single vascular component, namely the pericyte, contribute to the control of tumor oxygenation, macrophage polarization, vessel inflammation, and T cell infiltration. Switching...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39286984
DOI: 10.1172/JCI179860
PMCID: PMC11405053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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