Article

Catestatin suppresses melanoma progression and drug resistance through multitargeted modulation of signaling pathways

2025-10-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Despite advances in targeted and immune-based therapies, melanoma remains one of the most aggressive and treatment-resistant cancers. Resistance to small-molecule inhibitors and immune checkpoint blockade highlights the need for new mechanistically distinct interventions. Catestatin (CST), a Chromogranin A (CgA)– derived peptide with immunomodulatory and reparative propertie...

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Literature Corpus work: dcb84358-a9c8-54fb-a85e-647d4cfacf1d
DOI: 10.1101/2025.10.22.684062

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