Article
Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors
2021-03-30
Abstract excerpt
Tumor vasculature proliferates rapidly, generally lacks pericyte coverage, and is uniquely frag-ile making it an attractive therapeutic target. A subset of small-molecule tubulin binding agents cause disaggregation of the endothelial cytoskeleton leading to enhanced vascular permeability generating increased interstitial pressure. The resulting vascular collapse and ischemia cause downstream hypoxia, ultimately le...
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Identifiers and source
- Literature Corpus work
- 2e27f7b1-a6f7-532e-ae82-f3e8a0fcfd02
- DOI
- 10.20944/preprints202103.0736.v1