Article

CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivo

2024-04-12

Abstract excerpt

Tumors that arise in the epidermis must develop a vascular supply to grow beyond a millimeter in depth. This process requires CDC42 GTPases such as CDC42, RhoJ and RhoQ. Despite this dependence on angiogenesis for growth, melanoma tumors are minimally responsive to current anti-angiogenesis agents, highlighting the need for more effective drugs in this class. Here we integrate antibody infusion, optical tissue cle...

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Literature Corpus work: f3af6e44-c2a3-5a38-af77-4f616ca8c6ae
DOI: 10.1101/2024.04.09.588609

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