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Article

Common potential drug targets for ischemic stroke and coronary heart disease: CYR61, IL2RB, and ST3GAL2 are identified as key regulatory proteins.

International journal of biological macromolecules - 1 May 2026

Chen Miao, Liu Zongni, Lou Inmaculada Xu, Wan Haitong, Zhou Huifen

Abstract excerpt

BACKGROUND: Coronary heart disease (CHD) and ischemic stroke (IS) frequently co-occur; however, their shared molecular drivers remain poorly understood, limiting the development of dual-indication therapies. This study aims to characterize the bidirectional genetic relationship between CHD and IS and to prioritize shared candidate proteins as potential therapeutic targets or biomarkers. METHODS: Bidirectional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41999825
DOI: 10.1016/j.ijbiomac.2026.152034

Genes

IL2RB
ST3GAL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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