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Article

Monocyte Immunometabolic Axis Linking Type 2 Diabetes to Coronary Artery Disease Revealed by Multi-Omics Integration and Mendelian Randomization.

Circulation journal : official journal of the Japanese Circulation Society - 24 Jul 2026

Zhai Min, Bai Feng, Yan Rui, Liu Min

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) substantially increases coronary artery disease (CAD) risk, with residual risk unexplained by conventional factors. Immunometabolic dysregulation, particularly in monocytes, is implicated, but causal cell type-resolved evidence is limited. METHODS AND RESULTS: We integrated peripheral blood mononuclear cells' bulk and single-cell transcriptomes, identifying 1,799 differentially...

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Share to Coronary Artery Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41850863
DOI: 10.1253/circj.CJ-25-1057

Genes

CAD
ADM
ATG7
PGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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