Article

A framework for studying multi-omic risk factors and their interplay: application to coronary artery disease

2025-04-03

Abstract excerpt

<h4>Background</h4> Transcriptome-wide and proteome-wide association studies (TWAS and PWAS) have identified risk genes across complex diseases. However, the contributions of proximal risk variants and cross-omic interplay remain to be understood. <h4>Methods</h4> We propose an integrative framework to characterize disease-associated transcripts and proteins, and apply it to coronary artery disease (CAD). We emplo...

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Literature Corpus work: 90694ff3-f0e7-5b15-8bde-c11286f92684
DOI: 10.1101/2025.04.01.25324976

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