Article

Force-exerting lateral protrusions in fibroblastic cell contraction

2019-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Aligned extracellular matrix fibers enable fibroblasts to undergo myofibroblastic activation and lead to elongated cell morphology. The fibroblasts in turn contract to cause alignment of the extracellular matrix. This feedback process is critical in pathological occurrences such as desmoplasia and is not well understood. Using engineered fiber networks that serve as force sensors, we identify la...

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Literature Corpus work: 979b3b00-474f-507a-85c9-61b621008f7a
DOI: 10.1101/711507

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