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Mechanism of regulation of stem cell differentiation by matrix stiffness

26 May 2015

Abstract excerpt

Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by which stem cells respond to microenvironmental stiffness through the dynamics of the cytoskeletal...

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PMID: 26012510
DOI: 10.1186/s13287-015-0083-4

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