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Article

CircPVT1 weakens miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer

20 Mar 2025

Abstract excerpt

BACKGROUND: Altered metabolism is one of the cancer hallmarks. The role of circRNAs in cancer metabolism is poorly studied. Specifically, the impact of circPVT1, a well-known oncogenic circRNA on triple negative breast cancer metabolism is mechanistically underexplored. METHODS: The clinical significance of circPVT1 expression levels was assessed in human breast cancer samples using digital PCR and the cancer...

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PMID: 40114244
DOI: 10.1186/s13046-025-03355-1

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