Article
Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2.
Molecular cell - 18 Feb 2016
Redis Roxana S, Vela Luz E, Lu Weiqin, Ferreira de Oliveira Juliana, Ivan Cristina, Rodriguez-Aguayo Cristian, Adamoski Douglas, Pasculli Barbara, Taguchi Ayumu, Chen Yunyun, Fernandez Agustin F, Valledor Luis, Van Roosbroeck Katrien, Chang Samuel, Shah Maitri, Kinnebrew Garrett, Han Leng, Atlasi Yaser, Cheung Lawrence H, Huang Gilbert Y, Monroig Paloma, Ramirez Marc S, Catela Ivkovic Tina, Van Long, Ling Hui, Gafà Roberta, Kapitanovic Sanja, Lanza Giovanni, Bankson James A, Huang Peng, Lai Stephen Y, Bast Robert C, Rosenblum Michael G, Radovich Milan, Ivan Mircea, Bartholomeusz Geoffrey, Liang Han, Fraga Mario F, Widger William R, Hanash Samir, Berindan-Neagoe Ioana, Lopez-Berestein Gabriel, Ambrosio Andre L B, Gomes Dias Sandra M, Calin George A
Abstract excerpt
Altered energy metabolism is a cancer hallmark as malignant cells tailor their metabolic pathways to meet their energy requirements. Glucose and glutamine are the major nutrients that fuel cellular metabolism, and the pathways utilizing these nutrients are often altered in cancer. Here, we show that the long ncRNA CCAT2, located at the 8q24 amplicon on cancer risk-associated rs6983267 SNP, regulates cancer...
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