Article
Ras-MAPK pathway in patients with lupus nephritis.
Lupus science & medicine - 18 Mar 2025
Zhang Changming, Jing Xiaoman, Zhang Yangyang, Jin Ying, Gao Xingjian, Yu Jingxian, Liang Dandan, Zhang Jiahui, Zhong Qing, Zhang Haitao, Liu Zhihong
Abstract excerpt
BACKGROUND: Pathogenic mutations in genes encoding components of the Ras/mitogen-activated protein kinase (Ras-MAPK) pathway cause RASopathy. Here, we describe five unrelated patients with SLE carrying mutations associated with RASopathy and investigate the activity of the Ras-MAPK pathway. METHODS: Pathogenic variants were identified by whole-exome/whole-genome sequencing. The activity of the Ras-MAPK pathway in...
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