Article
Genetics of Lupus Nephritis: Clinical Implications.
Seminars in nephrology - 1 Sept 2015
Munroe Melissa E, James Judith A
Abstract excerpt
Systemic lupus erythematosus is a heterogeneous autoimmune disease marked by the presence of pathogenic autoantibodies, immune dysregulation, and chronic inflammation that may lead to increased morbidity and early mortality from end-organ damage. More than half of all systemic lupus erythematosus patients will develop lupus nephritis. Genetic-association studies have identified more than 50 polymorphisms that...
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