Article
Genetics of human lupus nephritis.
Seminars in nephrology - 1 Jan 2007
Morel Laurence
Abstract excerpt
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease in which glomerulonephritis represents one of the most severe clinical presentations. Numerous linkage and association studies, as well as the analysis of murine models, have provided ample evidence for a genetic basis for SLE. Genetic susceptibility to SLE results from the combined actions of multiple alleles, each of them conferring...
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