Article
Pathogenic Gene Spectrum and Clinical Implication in Chinese Patients with Lupus Nephritis.
Clinical journal of the American Society of Nephrology : CJASN - 1 Jul 2023
Zhang Changming, Han Xu, Jin Ying, Chen Xiang, Gong Cheng, Peng Jiahui, Wang Yusha, Luo Xiaoxin, Yang Zhaohui, Zhang Yangyang, Wan Weiguo, Liu Xiaohui, Mao Jianhua, Yu Haiguo, Li Jingyi, Liu Li, Sun Li, Yang Sirui, An Yu, Liu Zhengzhao, Gao Erzhi, Zhu Honghao, Chen Yinghua, Yu Xiaomin, Zhou Qing, Liu Zhihong
Abstract excerpt
BACKGROUND: Lupus nephritis is a rare immunological disorder. Genetic factors are considered important in its causation. We aim to systematically investigate the rare pathogenic gene variants in patients with lupus nephritis. METHODS: Whole-exome sequencing was used to screen pathogenic gene variants in 1886 probands with lupus nephritis. Variants were interpreted on the basis of known pathogenic variants or the...
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