Article

CAR Density Influences Antitumoral Efficacy of BCMA CAR T cells and Correlates with Clinical Outcome

2022-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Identification of new markers associated with long-term efficacy in patients treated with CAR T cells is a current medical need, particularly in diseases such as multiple myeloma. In this study we address the impact of CAR density on the functionality of BCMA-CAR T cells. Functional and transcriptional studies demonstrate that CAR T cells with high expression of the CAR construct show an increas...

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Literature Corpus work: 5a0f0809-0d2b-59b0-b291-7eb942f0476c
DOI: 10.1101/2022.01.19.22269515

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