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Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors

23 May 2023

Abstract excerpt

Chimeric antigen receptor (CAR) T cells demonstrate remarkable success in treating hematological malignancies, but their effectiveness in non-hematopoietic cancers remains limited. This study proposes enhancing CAR T cell function and localization in solid tumors by modifying the epigenome governing tissue-residency adaptation and early memory differentiation. We identify that a key factor in human...

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PMID: 37224816
DOI: 10.1016/j.xcrm.2023.101053

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