Polygenic risk scores for rheumatoid arthritis and idiopathic pulmonary fibrosis and associations with RA, interstitial lung abnormalities, and quantitative interstitial abnormalities among smokers.

doi:10.1016/j.semarthrit.2025.152708

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Article

Polygenic risk scores for rheumatoid arthritis and idiopathic pulmonary fibrosis and associations with RA, interstitial lung abnormalities, and quantitative interstitial abnormalities among smokers.

Seminars in arthritis and rheumatism - 1 Jun 2025

McDermott Gregory C, Moll Matthew, Cho Michael H, Hayashi Keigo, Juge Pierre-Antoine, Doyle Tracy J, Paudel Misti L, Kinney Gregory L, Kronzer Vanessa L, Kim John S, O'Keeffe Lauren A, Davis Natalie A, Bernstein Elana J, Dellaripa Paul F, Regan Elizabeth A, Hunninghake Gary M, Silverman Edwin K, Ash Samuel Y, San Jose Estepar Raul, Washko George R, Sparks Jeffrey A

Abstract excerpt

OBJECTIVE: Genome-wide association studies (GWAS) facilitate construction of polygenic risk scores (PRSs) for rheumatoid arthritis (RA) and idiopathic pulmonary fibrosis (IPF). We investigated associations of RA and IPF PRSs with RA and high-resolution chest computed tomography (HRCT) parenchymal lung abnormalities. METHODS: Participants in COPDGene, a prospective multicenter cohort of current/former smokers, had...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40090204
DOI: 10.1016/j.semarthrit.2025.152708
PMCID: PMC12048222

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