Genomic and Serological Rheumatoid Arthritis Biomarkers, MUC5B Promoter Variant, and Interstitial Lung Abnormalities.

doi:10.1513/AnnalsATS.202403-238OC

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Article

Genomic and Serological Rheumatoid Arthritis Biomarkers, MUC5B Promoter Variant, and Interstitial Lung Abnormalities.

Annals of the American Thoracic Society - 1 Jan 2025

Kim John S, Flack Kathryn F, Malik Vidhi, Manichaikul Ani, Sakaue Saori, Luo Yang, McGroder Claire F, Salvatore Mary, Anderson Michaela R, Hoffman Eric A, Podolanczuk Anna J, Yun Jae Hee, McDermott Gregory C, Sparks Jeffrey A, Putman Rachel, Moll Matthew, Rich Stephen S, Rotter Jerome I, Noth Imre, Raghu Ganesh, Giles Jon T, Winchester Robert, Raychaudhuri Soumya, Hunninghake Gary M, Cho Michael H, Garcia Christine Kim, Barr R Graham, Bernstein Elana J

Abstract excerpt

Rationale: Rheumatoid arthritis (RA) has been implicated in interstitial lung disease, as the majority of studies have comprised patients with known RA. However, it remains unclear whether an underlying risk for RA in combination with genetic risk for pulmonary fibrosis is associated with radiological markers of early lung injury and fibrosis in broader population samples. Objective: We sought to determine...

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Identifiers

PMID: 39405163
DOI: 10.1513/AnnalsATS.202403-238OC
PMCID: PMC11708761

Genes

MUC5B

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